Chan JTH, Liu Y, Khan S, St-Germain JR, Zou C, Leung LYT, Yang J, Shi M, Grunebaum E, Campisi P, Propst EJ, Holler T, Bar-Or A, Wither JE, Cairo CW, Moran MF, Palazzo AF, Cooper MD, Ehrhardt GRA. A tyrosine sulfation-dependent HLA-I modification identifies memory B cells and plasma cells. Sci Adv. 2018 4(11):eaar7653.

Palazzo, A.F., and Lee, E.S. Sequence Determinants for Nuclear Retention and Cytoplasmic Export of mRNAs and lncRNAs, 2018 Frontiers in Genetics 9 (440):1-16.

Voigt, F., Zhang, H., Cui, X.A., Liu, X.A, Eglinger, J., Lee, E.S., Chao, J.A. and Palazzo, A.F. Single-molecule quantification of translation-dependent association of mRNAs with the endoplasmic reticulum. Cell Reports, 2017, 21:3740-53.

Lee, E.S. and Palazzo, A.F. Assessing mRNA nuclear export in mammalian cells by microinjection. Methods, 2017, 126:76-85.

Kejiou, N. and Palazzo, A.F. mRNA Localization as a Rheostat to Regulate Subcellular Gene Expression. WIREs RNA, 2017 e1416.

Cenik, C., Chua, H.N., Singh, G., Akef, A., Snyder, M., Palazzo, A.F., Moore, M.J., and Roth, F. A A Common Class of Transcripts with 5'-Intron Depletion, Distinct Early Coding Sequence Features, and N1-Methyladenosine Modification. RNA, 2017 23:270-83 (preprint: bioRxiv, 2016 057455).

Palazzo, A.F. and Truong, M. Single particle imaging of mRNAs crossing the nuclear pore: surfing on the edge. Bioessays, 2016 38(8):744-50.

Akef, A., Lee, E.S. and Palazzo, A.F. Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements. RNA, 2015 21(11):1908-20.

Cui, X.A., Zhang, H, Ilan, L, Liu, A.X., Kharchuk, I., and Palazzo, A.F. mRNA encoding Sec61β, a tail-anchored protein, is localized on the endoplasmic rhgeticulum. Journal of Cell Science, 2015 128(18):3398-410

Lee, E.S., Akef, A., and Palazzo, A.F. The consensus 5’ splice site motif inhibits mRNA nuclear export. PLoS One, 2015 10 (3):e0122743.

Palazzo, A.F. and Lee, E.S. Non-coding RNA: what is functional and what is junk? Frontiers in Genetics, 2015 6(2):1-11.

Zhang, H, Mahadevan, K and Palazzo, A.F. Sumoylation is Required for the Cytoplasmic Accumulation of a Subset of mRNAs Genes, 2014 5(4):982-1000.

Palazzo, A.F. and Gregory, R.T. The Case for Junk DNA. PLoS Genetics, 2014 10(5): e1004351. doi:10.1371/journal.pgen.1004351.

Cui, X.A. and Palazzo, A.F. Localization of mRNAs to the Endoplasmic Reticulum. WIREs RNA, 2014 5(4):481-92.

Mahadevan, K., Zhang, H., Akef A., Cui, X.A., Gueroussov S., Cenik, C., Roth F.P. and Palazzo, A.F. RanBP2/Nup358 Potentiates the Translation of a Subset of mRNAs Encoding Secretory Proteins. PLoS Biology 2013, 11(4): e1001545.

Cui, X.A., Zhang, Y., Seo, J.H., and Palazzo, A.F. Identification of a region within the placental alkaline phosphatase mRNA that mediates p180-dependent targeting to the Endoplasmic Reticulum. Journal of Biological Chemistry, 2013 288(41):29633-29641.

Akef, A., Zhang, H., Masuda, S., and Palazzo, A.F. Trafficking of mRNAs containing ALREX-promoting elements through nuclear speckles. Nucleus, 2013, 4(4): 326-40.

Palazzo, A.F., Mahadevan, K., and Tarnawsky, S.P. ALREX-elements and introns: two identity elements that promote mRNA nuclear export. WIREs RNA, 2013, 4(5): 523-533.

Cui, X.A. and Palazzo A.F. Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells. J Vis Exp. 2012, 70:e50066.

Cui, X.A., Zhang, H. and Palazzo A.F. p180 Promotes the Ribosome-Independent Localization of a Subset of mRNA to the Endoplasmic Reticulum. PLoS Biology 2012, 10(5):e1001336.

Tarnawsky, S.P., and Palazzo, A.F. Positional requirements for the stimulation of mRNA nuclear export by ALREX-promoting elements. Molecular BioSystems 2012, 8(10) 2527-2530.

Palazzo, A.F., and Akef, A. Nuclear Export as a Key Arbiter of “mRNA Identity” in Eukaryotes. Biochimica et Biophysica Acta 2012, 1819(6):566-77.

Palazzo, A.F., and Mahadevan, K. Alternative Splicing Rewires Cellular Metabolism to Turn on the Warburg Effect. Biomedical Research 2012, 23:SI 23-30.

Cenik, C., Chua, H.N., Zhang, H, Tarnawsky, S., Akef, A., Derti, A., Tasan, M., Moore, M.J., Palazzo, A.F.*, and Roth, F.P.* Genome analysis reveals interplay between 5'UTR introns and nuclear mRNA export for secretory and mitochondrial genes. PLoS Genetics 2011, 7(4): e1001366. *co-corresponding authors.

Gueroussov, S., Tarnawsky, S.P., Cui, X.A., Mahadevan, K. and Palazzo, A.F. Analysis of mRNA Nuclear Export Kinetics in Mammalian Cells by Microinjection. J Vis Exp. 2010, 46. 

Alex Palazzo Publications, Pre-independent Researcher


Shibata, Y., Shemesh, T., Prinz, W.A., Palazzo, A.F., Kozlov, M.M.and Rapoport, T.A. Mechanisms determining the morphology of the peripheral ER. Cell. 2010, 143(5):774-88.

Palazzo, A.F., Springer, M., Shibata, Y., Lee, C.S., Dias, A.P. and Rapoport, T.A. The Signal Sequence Coding Region Promotes Nuclear Export of mRNA. PLoS Biol  2007, 5(12): e322.

Palazzo, A.F., Eng, C.H., Schlaepfer, D.D., Marcantonio, E.E. and Gundersen, G.G. Localized Stabilization of Microtubules by Integrin Facilitated Rho Signaling. Science 2004, 303:836-839.

Xiao D., Pinto J.T., Soh J.W., Deguchi A., Gundersen G.G., Palazzo A.F., Yoon J.T., Shirin H., Weinstein I.B. Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. Cancer Res 2003, 63:6825-6837.

Palazzo A.F., Ackerman B. and Gundersen G.G. Tubulin acetylation and cell motility. Nature 2003, 421: 230.

Palazzo A.F. and Gundersen, G. G. Microtubule-actin crosstalk at focal adhesions Science Signaling 2002, 139:PE31.

Saucier C., Papavasiliou V., Palazzo A., Naujokas M.A., Kremer R. and Park M. Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis Oncogene 2002, 21:1800-1811.

Yoon J.T., Palazzo A.F., Xiao D., DeloheryT.M., Warburton P.E., Bruce J.N., Thompson W.J., Sperl G., Whitehead C., Fetter J., Pamukcu R., Gundersen G.G. and Weinstein I.B. CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells Mol Cancer Ther 2002, 1:393-404.

Palazzo A.F., Joseph H.L., Chen Y.J., Dujardin D.L., Alberts A., Pfister K.K., Vallee R.B. and Gundersen G.G. Cdc42, dynein and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization Curr Biol 2001, 11: 1536-1541.

Palazzo A.F., Cook T.A., Alberts A. and Gundersen G.G. mDia mediates Rho-regulated formation and orientation of stable microtubules Nat Cell Biol 2001, 3: 723-729.

Yang H.C., Palazzo A., Swayne T.C. and Pon L.A. A retention mechanism for distribution of mitochondria during cell division in budding yeast Curr Biol 1999, 9:1111-1114.

Interviews and Profiles


08/18   Smith, K. The Palazzo Laboratory and ANE. Acute Necrotizing Awareness Day, ANE International.

03/15   Zimmer, C. Is Most of Our DNA Garbage? The New York Times Magazine.

05/14   Zimmer, C. The Case for Junk DNA. National Geographic – Phenomena: The Loom

08/12   Emerging Investigator Contributors 2012. Molecular BioSciences. 2012 8(10):2461-2465

01/11   Raper, V. Science Blogging and Tenure. Science Careers. 2011 doi: 10.1126/science.caredit.a1100007

2008    Williams, D. News from Departments, University of Toronto, Department of Biochemistry. CSBMCB Bulletin 2008. Page 84.

08/07   Wang, L. Friday Afternoons in the Lab. Chemical and Engineering News. 2007 85(34):88

05/07   Bonetta, L. Science enters the Blogosphere. Cell. 2007 129:443-445

09/06   Skipper, M., Would Mendel have been a blogger? Nature Reviews in Genetics. 2006 doi:10.1038/nrg1957